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Doped Ag-In-Zn-S and Ag-In-Ga-Zn-S QDs : synthesis and potential as dual-modality probes for magnetic resonance and fluorescence imaging of cells

Abstract : Since fluorescence imaging (FI) and magnetic resonance imaging (MRI) are among the most effective diagnostic tools, QDs with fluorescent and magnetic properties are of great interest as dual-modal probes. In this work, undoped and doped Ag-In-Zn-S (AIZS) and Ag-In-Ga-Zn-S (AIGZS) QDs were synthesized and investigated as bimodal probes for FI and MRI. Highly fluorescent AIZS QDs were prepared in organic media using DDT and OAm as capping ligands. Mn:AIZS QDs showed paramagnetic and superparamagnetic properties. AIZS and Mn:AIZS QDs were also transferred into aqueous phase using the amphiphilic PMAO polymer. Further, Mn, Gd or Fe-doped AIZS QDs were prepared in aqueous media, showed low cytotoxicity toward KB cells, and demonstrated potential as fluorescent probes for FI. Finally, AIGZS and Mn:AIGZS QDs, synthesized via a novel single precursor thermal decomposition method, showed high fluorescence and paramagnetic/superparamagnetic properties. Mn-doped aqueous transferred AIGZS QDs increased contrast in both T1-weighted and T2-weighted images with increasing in Mn loading.
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https://hal.univ-lorraine.fr/tel-03368106
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Submitted on : Wednesday, October 6, 2021 - 3:37:17 PM
Last modification on : Saturday, October 16, 2021 - 11:26:23 AM

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  • HAL Id : tel-03368106, version 1

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Perizat Galiyeva. Doped Ag-In-Zn-S and Ag-In-Ga-Zn-S QDs : synthesis and potential as dual-modality probes for magnetic resonance and fluorescence imaging of cells. Chemical and Process Engineering. Université de Lorraine, 2021. English. ⟨NNT : 2021LORR0118⟩. ⟨tel-03368106⟩

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