How the composition and manufacturing parameters affect insulin release from polymeric nanoparticles

Abstract : Polymeric nanoparticles (PLA-PCL-Eudragit (R) RS-ethylcellulose-PVA) containing insulin were prepared by a double emulsion (W/O/W) solvent evaporation technique. The quantification of insulin in the particles was performed by HPLC analysis; the particles were characterized by different techniques, namely DSC, SEM and infrared analysis. The parameters of the preparation process were optimized. The encapsulation efficacy could be increased up to 99%, using PCL 60000/Eudragit (R) RS. The nature of the polymers also affected the size and zeta potential of the nanoparticles and insulin release kinetics. The use of ethylcellulose in the formulation and ultrasound during nanoparticle preparation allowed obtaining particles smaller than 300 nm.
Type de document :
Article dans une revue
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2015, 30, pp.458-466. 〈10.1016/j.jddst.2015.09.012〉
Domaine :
Liste complète des métadonnées

https://hal.univ-lorraine.fr/hal-01274924
Contributeur : Cithefor Ul <>
Soumis le : mardi 16 février 2016 - 14:28:30
Dernière modification le : mercredi 17 février 2016 - 01:07:13

Identifiants

Collections

Citation

Nassiba Mimi, Hayet Belkacemi, Tahar Sadoun, Anne Sapin, Philippe Maincent. How the composition and manufacturing parameters affect insulin release from polymeric nanoparticles. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2015, 30, pp.458-466. 〈10.1016/j.jddst.2015.09.012〉. 〈hal-01274924〉

Partager

Métriques

Consultations de la notice

47