Chitosan nanoparticles and quercetin modulate gene expression and prevent the genotoxicity of aflatoxin B1 in rat liver

Abstract : The aims of the current study were to prepare chitosan nanoparticles (CNPs) and to evaluate its protective role alone or in combination with quercetin (Q) against AFB1-induce cytotoxicity in rats. Male Sprague-Dawley rats were divided into 12 groups and treated orally for 4 weeks as follow: the control group, the group treated with AFB1 (80 μg/kg b.w.) in corn oil, the groups treated with low (140 mg/kg b.w.) or high (280 mg/kg b.w.) dose of CNPs, the group treated with Q (50 mg/kg b.w.), the groups treated with Q plus the low or the high dose of CNPs and the groups treated with AFB1 plus Q and/or CNPs at the two tested doses. The results also revealed that administration of AFB1 resulted in a significant increase in serum cytokines, Procollagen III, Nitric Oxide, lipid peroxidation and DNA fragmentation accompanied with a significant decrease in GPx I and Cu–Zn SOD-mRNA gene expression. Q and/or CNPs at the two tested doses overcome these effects especially in the group treated with the high dose of CNPs plus Q. It could be concluded that CNPs is a promise candidate as drug delivery enhances the protective effect of Q against the cytogenetic effects of AFB1 in high endemic areas.
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Toxicology Reports, 2015, 2, pp.737-747. 〈10.1016/j.toxrep.2015.05.007〉
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https://hal.univ-lorraine.fr/hal-01281140
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Soumis le : mardi 1 mars 2016 - 16:34:53
Dernière modification le : mardi 10 mai 2016 - 11:30:48

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Mosaad A. Abdel-Wahhab, Abdulhadi Aljawish, Aziza A. El-Nekeety, Sekena H. Abdel-Aiezm, Heba A. M. Abdel-Kader, et al.. Chitosan nanoparticles and quercetin modulate gene expression and prevent the genotoxicity of aflatoxin B1 in rat liver. Toxicology Reports, 2015, 2, pp.737-747. 〈10.1016/j.toxrep.2015.05.007〉. 〈hal-01281140〉

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