C-Functionalized chiral dioxocyclam and cyclam derivatives with 1,2,3-triazole units: synthesis, complexation properties and crystal structures of copper(II) complexes

Abstract : New C-functionalized syn- and anti-dioxocyclam and cyclam derivatives with 1,2,3-triazole units attached to carbon atoms within the skeleton were designed as valuable bifunctional chelating agents for applications in nuclear medicine. These macrocyclic chelators were prepared via a multi-step sequence involving alpha- and beta-amino acids, and their copper(II) complexation properties were evaluated. A solution structure in which the triazoles are in axially coordinating positions was proposed for the [Cu(anti-27)](2+) complex. Promising results have been obtained regarding the complexation kinetics (<10 s) and the pseudo-first order half-life for acid-assisted dissociation (t(1/2) = 3.21 d, 5 M HCl, 50 degrees C).
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New Journal of Chemistry, Royal Society of Chemistry, 2016, 40 (2), pp.1507-1520. 〈10.1039/c5nj01927c〉
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https://hal.univ-lorraine.fr/hal-01495195
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Soumis le : vendredi 24 mars 2017 - 16:22:31
Dernière modification le : mardi 16 janvier 2018 - 10:24:44

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A. -S. Fetten, N. Petry, B. Henry, Nadia Pellegrini-Moïse, Katalin Selmeczi. C-Functionalized chiral dioxocyclam and cyclam derivatives with 1,2,3-triazole units: synthesis, complexation properties and crystal structures of copper(II) complexes. New Journal of Chemistry, Royal Society of Chemistry, 2016, 40 (2), pp.1507-1520. 〈10.1039/c5nj01927c〉. 〈hal-01495195〉

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