Microscopic gel-liquid interfaces supported by hollow microneedle array for voltammetric drug detection - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue Sensors and Actuators B: Chemical Année : 2014

Microscopic gel-liquid interfaces supported by hollow microneedle array for voltammetric drug detection

Résumé

This report describes a method for integration of a gel-liquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43 nA mu M-1, a limit of detection of 50 nM and a linear range between 50 and 200 nM.
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Dates et versions

hal-01505217 , version 1 (09-11-2018)

Identifiants

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Patricia Vazquez, Grégoire Herzog, Conor O'Mahony, Joseph O'Brien, James Scully, et al.. Microscopic gel-liquid interfaces supported by hollow microneedle array for voltammetric drug detection. Sensors and Actuators B: Chemical, 2014, 201, pp.572-578. ⟨10.1016/j.snb.2014.04.080⟩. ⟨hal-01505217⟩
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