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Assembly of Gamma-Tubulin Ring Complexes: Implications for Cell Biology and Disease

Abstract : Microtubules are among the main constituents of the cytoskeleton. They are assembled from dimers of alpha- and beta-tubulin. This assembly occurs preferentially at organizing centers such as the centrosomes, catalyzed by multiprotein complexes of gamma-tubulin. At the beginning of mitosis, the amount of gamma-tubulin complexes at the centrosomes increases sharply, supporting the sudden formation of numerous spindle microtubules. Recent studies on the structure of gamma-tubulin complex proteins have advanced our understanding of the assembly process of gamma-tubulin complexes, and have pointed toward putative mechanisms of microtubule nucleation. Moreover, the discovery of novel proteins associated with gamma-tubulin complexes has illustrated the possibilities of how gamma-tubulin might be recruited and regulated at specific sites of microtubule organization. This chapter highlights recent developments in the field and discusses the potential of the gamma-tubulin complex as a pharmacological target, to control proliferation of cells.
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Marie-Hélène Remy, Andreas Merdes, Lynn Gregory-Pauron. Assembly of Gamma-Tubulin Ring Complexes: Implications for Cell Biology and Disease. Giraldo, J and Ciruela, F. OLIGOMERIZATION IN HEALTH AND DISEASE, 117, pp.511-530, 2013, Progress in Molecular Biology and Translational Science, 978-0-12-386931-9. ⟨10.1016/B978-0-12-386931-9.00019-2⟩. ⟨hal-01561289⟩



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