Relative bioavailability of soil-bound chlordecone in growing lambs

Abstract : The pollution of soil with the pesticide chlordecone (CLD) is a problem for the use of agricultural surfaces even years after its use has been forbidden. Therefore, the exposure of free-ranged animals such as ruminants needs to be investigated in order to assess the risk of contamination of the food chain. Indeed, measured concentrations could be integrated in a lowered extent if the soil binding would reduce the bioavailability of the pesticide. This bioavailability of soil-bound CLD in a heavily polluted andosol has been investigated relatively of CLD given via spiked oil. Twenty-four weaned lambs were exposed to graded doses of 2, 4 or 6 mu g CLD/kg body weight during 15 days via the contaminated soil in comparison to spiked oil. The concentration of this pesticide has been determined in two target tissues: blood serum and kidney fat. The relative bioavailability (RBA) corresponds to the slope ratio between the test matrix-contaminated soil- in comparison to the reference matrix oil. The RBA of the soil-bound CLD was not found to significantly differ from the reference matrix oil in lambs meaning that the pesticide ingested by grazing ruminants would not be sequestered by soil binding. Therefore, CLD from soil gets bioavailable within the intestinal level and exposure to contaminated soil has to be integrated in risk assessments.
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Article dans une revue
Environmental Geochemistry and Health, Springer Verlag (Germany), 2014, 36 (5, SI), pp.911-917. 〈10.1007/s10653-014-9608-5〉
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https://hal.univ-lorraine.fr/hal-01562171
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Soumis le : jeudi 13 juillet 2017 - 16:35:48
Dernière modification le : lundi 19 mars 2018 - 15:08:31

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S. Jurjanz, C. Jondreville, M. Mahieu, A. Fournier, H. Archimede, et al.. Relative bioavailability of soil-bound chlordecone in growing lambs. Environmental Geochemistry and Health, Springer Verlag (Germany), 2014, 36 (5, SI), pp.911-917. 〈10.1007/s10653-014-9608-5〉. 〈hal-01562171〉

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