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Master thesis

Evaluation de l'inflammation synoviale par IRM, avant et après une injection intra-articulaire d'IL-1Ra (Anakinra) chez 7 patients souffrant de gonarthrose

Abstract : To explore the potential effect of one single intra-articular injection of IL-1Ra (anakinra) in 7 patients with knee osteoarthrisis we evaluate with MRI synovial inflammation before and after injection. Visual Analog Scale for pain and WOMAC were recorded at day 0, 1, 4, week 4, 8 and 12. Synovial membrane inflammation was evaluated by MRI on a 1,5 T scanner. Sagittal 3D-FGRE fat-supressed and axial SE fat-supressed sequences were performed before and after contrast agent injection in order to evaluate synovial inflammation according three different manners: MRI total score, evaluation of the synovial membrane volume and percentage of active synovial membrane. The joint effusion was also graded as mild, moderate or severe on T2-weighted sequence.The pharmacokinetic data obtained at 0h, 1h, 2h, 4h, 8h, 12h, 24h, 36h and 48h after intra-articular injection were presented in terms of maximal concentration and maximal time of residence in blood. IL-1Ra reduced the MRI total score from 8,71 +/- 1,38 to 6,71 +/- 0,97 36h after intra-articular injection. No statistical significiant change were noted on synovial membrane volume, percentage of active synovial membrane and joint effusion scores. These results suggest an anti-inflammatory effect of IL-1Ra on MRI total synovial score performed at 36 hours, parralell to a clinical improvement observed at day 4.
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Master thesis
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https://hal.univ-lorraine.fr/hal-01733933
Contributor : Colette Orange <>
Submitted on : Wednesday, March 14, 2018 - 4:16:13 PM
Last modification on : Friday, October 23, 2020 - 4:58:43 PM
Long-term archiving on: : Wednesday, September 5, 2018 - 11:31:16 AM

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  • HAL Id : hal-01733933, version 1

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Hervé Dintinger. Evaluation de l'inflammation synoviale par IRM, avant et après une injection intra-articulaire d'IL-1Ra (Anakinra) chez 7 patients souffrant de gonarthrose. Sciences du Vivant [q-bio]. 2005. ⟨hal-01733933⟩

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