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Master thesis

De l'adiposité lipodystrophique au syndrome métabolique sévère: une étude de 600 personnes par absorptiométrie biphotonique

Abstract : Introduction : Similarly to the partial lipodystrophies, excess abdominal fat deposition associated to a lack of fat deposition in the legs could be related to a severe metabolic syndrome (MS) according to ATP III definition. Moreover, it could be a major marker for cardiovascular disorders (CVD) and diabetes mellitus (DM).Methods : We studied the relation between biological and clinical parameters, CVD and body fat distribution (Dual-Energy X-Ray Absorptiometry) among 600 outpatients (376 women and 224 men) consulting in the Department of Diabetology, Metabolic Diseases, and Nutrition at Nancy University Hospital. The population was divided in quartiles according to abdominal/legs fat mass (%) ratio (AIL). Results : In our population, the MS frequency was 62 % for men and 42,s % for women. The more the subjects were lipodystrophic, the more MS were severe and the higher the risk for CVD and DM. In step by step regression analysis for women, the first parameter associated with severe MS was L/G vs. abdominal fat mass (%) for men. The prevalence of Coronary Heart Disease for men who had a severe MS (5 criteria) associated with lipodystrophy was37,5 % vs. 19 % for those who didn't. This prevalence grew up to 46,l % against 18,3 % if BMI if BMI was below 35kg/m2.Conclusion : Lipodystrophic fat deposition, or lipodystrophic adiposity, is highly related to severe MS. When both are associated, it reveals an exceptionally severe metabolic climate called "super X syndrome", which seems tobe a major CVD risk factor.
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Master thesis
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Submitted on : Wednesday, March 14, 2018 - 4:43:06 PM
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Dominique Tourpe. De l'adiposité lipodystrophique au syndrome métabolique sévère: une étude de 600 personnes par absorptiométrie biphotonique. Sciences du Vivant [q-bio]. 2007. ⟨hal-01734487⟩



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