Estimating the prevalence of systemic sclerosis in the Lorraine region, France, by the capture-recapture method

Abstract : Objective: To assess prevalence of systemic sclerosis (SSc) in the Lorraineregion, France.Methods: Data from 3 sources - general practitioners and community and hospitalspecialists, medical records departments, and regional and national laboratories -and a capture-recapture method with log-linear models were used to estimate SScprevalence in the region. Double recording was checked, and reported cases werevalidated after a review of medical records.Results: We identified 560 records of probable SSc corresponding to 327 uniqueprobable SSc cases existing on June 30, 2006, in Lorraine. On the basis of the 193validated cases (22 [11.4%] with diffuse disease, 136 [70.5%] with limited disease, 31 [16.1%] with limited involvement and 4 unknown), the observed overall crude prevalence of SSc was 105.4 cases per million adult inhabitants (95% confidence interval [CI]: 91.0;121.4). With the capture-recapture method, the estimated number of SSc cases was 233 (95% CI: 217.3;260.0), so an estimated 40 cases were not identified by the 3 sources. The estimated overall prevalence was 132.2 cases per million adult inhabitants (95% CI: 115.8;154.0).Conclusions: Our study provides the first estimate of SSc prevalence in the Lorraineregion. The capture-recapture method allowed us to estimate an additional 21% ofunobserved cases and is a good alternative to the community-based study design for estimating the prevalence of rare diseases
Document type :
Master thesis
File URL :
http://docnum.univ-lorraine.fr/prive/SCDMED_T_2011_EL_ADSSI_VIRDOL_HARITINA.pdf
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https://hal.univ-lorraine.fr/hal-01770709
Contributor : Colette Orange <>
Submitted on : Thursday, April 19, 2018 - 10:57:50 AM
Last modification on : Thursday, April 19, 2018 - 10:57:50 AM

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Haritina El Adssi Virdol. Estimating the prevalence of systemic sclerosis in the Lorraine region, France, by the capture-recapture method. Life Sciences [q-bio]. 2011. ⟨hal-01770709⟩

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