HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Denosumab-related osteonecrosis of the jaw: A retrospective study

Abstract : Background: Osteonecrosis of the jaw is a very delicate side effect of Denosumab. The aim of this retrospective study was to assess the occurrence rate of Denosumab‐related osteonecrosis of the jaw (DRONJ) at the Cancer Institute of Lorraine (ICL) and to highlight necrosis risk factors. Methods: To that purpose, we analyzed the medical records of 249 consecutive patients treated with Denosumab at the ICL during the past 5 years. Patients who received orofacial radiotherapy or a previous treatment with a bisphosphonate were excluded. The P‐value was set at .005. Results: A total of 141 patients treated at the ICL between January 2010 and December 2015 were included. All patients were treated with XGEVA®. Of the 141 patients included in the study, 10 developed DRONJ. The incidence of DRONJ increases with the duration of follow‐up as follows: 3% at 1 year, 7% at 2 years, and 8% from 30 months on. No risk factor for necrosis could be identified except the realization of prior dental extraction (P = .025). Conclusion: Our results raise important questions about the dental management of these patients, in particular, concerning the healing period between dental extractions and the initiation of Denosumab.
Document type :
Journal articles
Complete list of metadata

Contributor : Claire Egloff-Juras Connect in order to contact the contributor
Submitted on : Tuesday, December 18, 2018 - 10:28:56 AM
Last modification on : Wednesday, November 3, 2021 - 8:17:59 AM




Claire Egloff-Juras, Aurélie Gallois, Julia Salleron, Vincent Massard, Gilles Dolivet, et al.. Denosumab-related osteonecrosis of the jaw: A retrospective study. Journal of Oral Pathology and Medicine, Wiley, 2018, 47 (1), pp.66-70. ⟨10.1111/jop.12646⟩. ⟨hal-01958613⟩



Record views