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In situ glyco-nanostructure formulation via photo-polymerization induced self-assembly

Abstract : Frequently, the classical self-assembly techniques applied to amphiphilic glycopolymers lead to primitive morphologies, i.e. spherical micelles/nanoparticles. Herein, we report a facile and rapid one-pot synthesis and self-assembly of grafted amphiphilic glycopolymers using photo-initiated Polymerization-Induced Self-Assembly (Photo-PISA) under UV-irradiation at room temperature. Such glycopolymers were based on dextran as a hydrophilic steric stabilizer backbone and poly(hydroxypropyl methacrylate) PHPMA as a hydrophobic graft. Transmission electron microscopy and light scattering analysis reveal the formation of a broad set of advanced glyco-nanostructures ranging from spherical micelles to worm-like micelles and vesicles depending on both the PHPMA graft length and the solids content.
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Submitted on : Tuesday, March 5, 2019 - 7:48:56 PM
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Khalid Ferji, Pierre Venturini, Franck Cleymand, Christophe Chassenieux, Jean-Luc Six. In situ glyco-nanostructure formulation via photo-polymerization induced self-assembly. Polymer Chemistry, Royal Society of Chemistry - RSC, 2018, 9 (21), pp.2868-2872. ⟨10.1039/C8PY00346G⟩. ⟨hal-02058224⟩



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