Bacteriophilic tetra-p-guanidinoethyl-calix[4]arene derived polymers. Syntheses and E. coli sequestration studies

Abstract : The antibacterial tetracationic tetra-p-guanidinoethylcalix[4]arene developed by our team has been anchored through bottom-up or top-down pathways to the surface of Merrifield and Wang benzaldehyde resins; the attachment involved either a pyridinium linker or an imine/amine one. The grafting yields were evaluated by elemental analysis through the nitrogen content. Their sequestering properties towards bacteria were evaluated, using E. coli as a model, by capillary electrophoresis (CE) which showed their efficiencies and their bacteriophilic behaviors. All the new materials were compared to two pyridinium-derived Merrifield resins in terms of effective capture, efficiency, and removal coefficients, showing that some of these calixarene-derived resins are good bacteriophilic materials. Confirmation of such behavior has been provided by microscopy.
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https://hal.univ-lorraine.fr/hal-02086407
Contributor : Jean-Bernard Regnouf de Vains <>
Submitted on : Monday, April 1, 2019 - 12:34:32 PM
Last modification on : Wednesday, September 4, 2019 - 2:06:04 PM

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Frédéric Lemée, Maxime Mourer, Lionel Aranda, Igor Clarot, Jean-Bernard Regnouf-De-Vains. Bacteriophilic tetra-p-guanidinoethyl-calix[4]arene derived polymers. Syntheses and E. coli sequestration studies. New Journal of Chemistry, Royal Society of Chemistry, 2016, 40 (10), pp.8239-8250. ⟨10.1039/C6NJ01563H⟩. ⟨hal-02086407⟩

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