Nano or Micro: 3 Different Particles to Deliver and Protect S-Nitrosoglutathione for Oral Route Administration

Abstract : As a physiological nitric oxide donor, S-nitrosoglutathione (GSNO) is a promising candidate for several diseases (e.g., stroke and atherosclerosis). However, its clinical application has been limited by its low stability. In order to protect GSNO suitable for oral route administration and to achieve sustained release, 3 different particles from nano-size to micro-size were obtained by a water-in-oil-in-water (W/O/W) or solid-in-oil-in-water (S/O/W) double emulsion/solvent evaporation method. The 3 different particles tuned out to have similar encapsulation efficiency while the microparticles showed longer release time. Finally, the 3 formulations have been successfully lyophilized for long term stability.
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Yi Zhou, Caroline Gaucher, Isabelle Fries, Marianne Parent. Nano or Micro: 3 Different Particles to Deliver and Protect S-Nitrosoglutathione for Oral Route Administration. Natural Products and the Hallmarks of Chronic Diseases - NutRedOx COST Action 16112, Mar 2019, Luxembourg, Luxembourg. pp.14, ⟨10.3390/proceedings2019011014⟩. ⟨hal-02132107⟩

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