In this paper, the mineralogy, fluid inclusions and stable isotopes of hydrothermal veins from the SE part of the Afar Rift (Djibouti) were studied. Mineralization occurs as gold-silver in quartz/carbonate veins and is mainly associated with felsic volcanism. The morphologies and textures of quartz show crustiform colloform banding, massive and breccias. Microthermometric measurements were made on quartzhosted two phases (liquid + vapor) inclusions. Mean homogenization temperature ranges from 150°C to 340°C and ice-melting temperatures range from-0.2°C to-1.6°C indicating that inclusion solutions contain 0.35 to 2.7 eq. wt. % NaCl. Furthermore, δ18O and δ13C values from calcite range from 3.7 to 26.6 ‰ and-7.5 to 0.3 ‰, respectively. The presence of platy calcite and adularia are consistent with boiling conditions. Our study shows that the deposit of precious-metal deposition occurred at around 250°C and is linked to a fluid generated by the mixture of magmatic fluid, hydrothermal fluid and seawater. Please note that this is an author-produced PDF of an article accepted for publication following peer review. The definitive publisher-authenticated version is available on the publisher Web site.