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Effects of metabolic syndrome on arterial function in different age groups: the Advanced Approach to Arterial Stiffness study

Jirar Topouchian 1 Carlos Labat 2 Sylvie Gautier 3 Magnus Bäck 2, 4 Apostolos Achimastos 5 Jacques Blacher 1 Marcin Cwynar 6 Alejandro de La Sierra 7 Denes Pall 8 Francesco Fantin 9 Katalin Farkas 10 Luis Garcia-Ortiz 11, 12 Zoya Hakobyan 13 Piotr Jankowski 14 Ana Jelakovic 15 Zhanna Kobalava 16 Alexandra Konradi 17 Yulia Kotovskaya 16, 18 Marina Kotsani 19 Irina Lazareva 20 Alexander Litvin 21 Viktor Milyagin 22 Iveta Mintale 23 Oscar Persson 4 Rafael Ramos Anatoly Rogoza Ligita Ryliskyte Angelo Scuteri Yuriy Sirenko Georges Soulis Nebojsa Tasic Maryna Udovychenko Saule Urazalina Peter Wohlfahrt Parounak Zelveian Athanase Benetos 2, 3 Roland Asmar 24 
Abstract : OBJECTIVE: The aim of the Advanced Approach to Arterial Stiffness study was to compare arterial stiffness measured simultaneously with two different methods in different age groups of middle-aged and older adults with or without metabolic syndrome (MetS). The specific effects of the different MetS components on arterial stiffness were also studied. METHODS: This prospective, multicentre, international study included 2224 patients aged 40 years and older, 1664 with and 560 without MetS. Patients were enrolled in 32 centres from 18 European countries affiliated to the International Society of Vascular Health & Aging. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) and the carotid-femoral pulse wave velocity (CF-PWV) in four prespecified age groups: 40-49, 50-59, 60-74, 75-90 years. In this report, we present the baseline data of this study. RESULTS: Both CF-PWV and CAVI increased with age, with a higher correlation coefficient for CAVI (comparison of coefficients P < 0.001). Age-adjusted and sex-adjusted values of CF-PWV and CAVI were weakly intercorrelated (r = 0.06, P < 0.001). Age-adjusted and sex-adjusted values for CF-PWV but not CAVI were higher in presence of MetS (CF-PWV: 9.57 ± 0.06 vs. 8.65 ± 0.10, P < 0.001; CAVI: 8.34 ± 0.03 vs. 8.29 ± 0.04, P = 0.40; mean ± SEM; MetS vs. no MetS). The absence of an overall effect of MetS on CAVI was related to the heterogeneous effects of the components of MetS on this parameter: CAVI was positively associated with the high glycaemia and high blood pressure components, whereas lacked significant associations with the HDL and triglycerides components while exhibiting a negative association with the overweight component. In contrast, all five MetS components showed positive associations with CF-PWV. CONCLUSION: This large European multicentre study reveals a differential impact of MetS and age on CAVI and CF-PWV and suggests that age may have a more pronounced effect on CAVI, whereas MetS increases CF-PWV but not CAVI. This important finding may be due to heterogeneous effects of MetS components on CAVI. The clinical significance of these original results will be assessed during the longitudinal phase of the study.
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Submitted on : Monday, April 6, 2020 - 11:29:20 AM
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Jirar Topouchian, Carlos Labat, Sylvie Gautier, Magnus Bäck, Apostolos Achimastos, et al.. Effects of metabolic syndrome on arterial function in different age groups: the Advanced Approach to Arterial Stiffness study. Journal of Hypertension, Lippincott, Williams & Wilkins, 2018, 36 (4), pp.824-833. ⟨10.1097/HJH.0000000000001631⟩. ⟨hal-02533105⟩



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