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Left ventricular myocardial deformation pattern, mechanical dispersion, and their relation with electrocardiogram markers in the large population-based STANISLAS cohort: insights into electromechanical coupling

Abstract : BACKGROUND: Mechanical alterations in patients with electrical conduction abnormalities are reported to have prognostic value in patients with left ventricular asynchrony or long QT syndrome beyond ECG variables. Whether conduction and repolarization patterns derived from ECG are associated with speckle tracking echocardiography (STE) parameters in subjects without overt cardiac disease is yet to be investigated.OBJECTIVES: To report ranges of longitudinal deformation according to conduction and repolarization values in a population-based cohort.METHODS: 1140 subjects (48.6±14.0 years, 47.7% men) enrolled in the 4th visit of the STANISLAS cohort (Lorraine, France) were studied. Echocardiography strain was performed in all subjects. RR, PR, QRS and QT intervals were retrieved from digitalized twelve-lead ECG. Echocardiographic data were stratified according to quartiles of QRS and QTc duration values.RESULTS: Full-wall global longitudinal strain (GLS) was -21.1%±2.5% with a mechanical dispersion value of 33.6±11.7ms. Absolute GLS value was lower in the longest QRS quartile and shortest QTc quartile (both p<0.001). Time-to-peak of strain was not significantly different according to QRS duration although significantly higher in patients with higher QTc (p<0.001). Mechanical dispersion was significantly greater in patients with longer QTc (32.4±11.7ms for QTc<396ms versus 35.8±11.9ms for QTc>421ms; p=0.002). CONCLUSIONS: Longer QTc is related to increased MD and better longitudinal strain values. In a population-based setting, QRS is not associated with MD, suggesting that echocardiography-based dyssynchrony does not largely overlap with ECG-based dyssynchrony
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https://hal.univ-lorraine.fr/hal-02881977
Contributor : Erwan Bozec <>
Submitted on : Friday, June 26, 2020 - 11:23:09 AM
Last modification on : Thursday, March 11, 2021 - 2:26:02 PM

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Mario Verdugo-Marchese, Stefano Coiro, Christine Selton-Suty, Masatake Kobayashi, Erwan Bozec, et al.. Left ventricular myocardial deformation pattern, mechanical dispersion, and their relation with electrocardiogram markers in the large population-based STANISLAS cohort: insights into electromechanical coupling. European Heart Journal - Cardiovascular Imaging, Oxford UP, 2020, 21 (11), pp.1237-1245. ⟨10.1093/ehjci/jeaa148⟩. ⟨hal-02881977⟩

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