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Increased gingival crevicular fluid levels of soluble triggering receptor expressed on myeloid cells (sTREM) -1 in severe periodontitis

Abstract : Increased gingival crevicular fluid levels of soluble triggering receptor expressed on myeloid cells (sTREM)-1 in severe periodontitis Bisson C, Massin F, Lefevre PA, Thilly N, Miller N, Gibot S. Increased gingival crevicular fluid levels of soluble triggering receptor expressed on myeloid cells (sTREM)-1 in severe periodontitis. Abstract Aim: This study was designed to evaluate the presence of a new regulator of innate immunity in periodontitis: the soluble form of triggering receptor on myeloid cells-1 (sTREM-1) in gingival crevicular fluid (GCF). Material and Methods: GCF was collected at four sites, three pathological and one healthy from 17 patients with periodontitis, and at one healthy site from 23 control patients. An enzyme-linked immunosorbent assay (ELISA) kit was used to quantify sTREM-1 levels in collected crevicular fluid. Recorded clinical parameters were probing pocket depth (PPD), bleeding upon probing, tooth mobility, plaque index (PlI), and gingival index (GI). Results: The mean sTREM-1 level in collected fluid was significantly higher in pathological sites than in healthy sites from either periodontal or control patients: 353.9 pg/ml, 50.2 pg/ml and 25.4 pg/ml respectively. Soluble TREM-1 concentration was significantly correlated with PPD. The sTREM-1 levels increased with the augmentation of the PlI and GI scores and levelled off at score 2 for both indexes. In multivariate analysis, periodontal pocket depth and smoking status were statistically associated with highest sTREM-1 concentrations. Conclusion: sTREM-1 was detected in crevicular fluid and its concentration was higher in pathological sites. It could be a marker of periodontal tissue destruction.
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https://hal.univ-lorraine.fr/hal-02987406
Contributor : Catherine Bisson <>
Submitted on : Wednesday, February 10, 2021 - 11:40:01 AM
Last modification on : Friday, February 12, 2021 - 3:20:59 AM

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Catherine Bisson, Frédéric Massin, Pierre Lefevre, Nathalie Thilly, Neal Miller, et al.. Increased gingival crevicular fluid levels of soluble triggering receptor expressed on myeloid cells (sTREM) -1 in severe periodontitis. Journal of Clinical Periodontology, Wiley, 2012, 39, pp.1141 - 1148. ⟨10.1111/jcpe.12008⟩. ⟨hal-02987406⟩

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