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Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology

Abstract : Objectives Today, the increase of invasive fungal infections and the emergence of resistant strains are observed in medical practice. New antifungals are expected, and the plant world offers a panel of potentially active molecules. CIN-102 is a mixture of seven different compounds of plant origin developed from the formulation of cinnamon essential oil. Methods The in vitro activity of CIN-102 was characterised against Aspergillus spp., Fusarium spp. and Scedosporium spp. by studying the minimum inhibitory concentration (MIC), inoculum effect, germination inhibition, fungal growth, post-antifungal effect (PAFE) and synergy. Results MICs determined for the three genera followed a unimodal distribution and their mean values ranged from 62–250 μg/mL. CIN-102 demonstrated an inoculum effect similar to voriconazole and amphotericin B, 100% inhibition of spore germination and a PAFE. Conclusion CIN-102 has significant activity against filamentous fungi involved in human pathologies and should be further explored as a potential new treatment. Other studies regarding its mechanisms of action as well as animal investigations are awaited
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https://hal.univ-lorraine.fr/hal-03210125
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Submitted on : Tuesday, April 27, 2021 - 5:20:18 PM
Last modification on : Tuesday, May 4, 2021 - 3:16:25 AM

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Maurine d'Agostino, Nicolas Tesse, Rose Anne Lavergne, Patrice Le Pape, Jean Philippe Bouchara, et al.. Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology. Journal of Global Antimicrobial Resistance, Elsevier, 2021, 25, pp.171-180. ⟨10.1016/j.jgar.2021.03.017⟩. ⟨hal-03210125⟩

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