Synthetic Modifications of the Linkage Region of Proteoglycans and Impact on CSGalNAcT‐1 - Archive ouverte HAL Access content directly
Journal Articles European Journal of Organic Chemistry Year : 2022

Synthetic Modifications of the Linkage Region of Proteoglycans and Impact on CSGalNAcT‐1

Abstract

Multi-step synthesis of a library of variously modified disaccharides and trisaccharides of the linkage region of proteoglycans (PGs) having a d-galactose modified at position C-2, C-4 or C-6 position by replacing the hydroxyl group by methoxy or deoxy moieties is described. Preliminary results of the impact of these modifications upon CSGalNAcT-1 are also reported.
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hal-03564227 , version 1 (10-02-2022)

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Benjamin Ayela, Floriane Heis, Thomas Poisson, Xavier Pannecoucke, Sylvie Fournel‐gigleux, et al.. Synthetic Modifications of the Linkage Region of Proteoglycans and Impact on CSGalNAcT‐1. European Journal of Organic Chemistry, 2022, 2022 (2), pp.e202101422. ⟨10.1002/ejoc.202101422⟩. ⟨hal-03564227⟩
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