Encapsulation of salmon peptides in marine liposomes: physico-chemical properties, antiradical activities and biocompatibility assays - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue Marine drugs Année : 2022

Encapsulation of salmon peptides in marine liposomes: physico-chemical properties, antiradical activities and biocompatibility assays

Résumé

Salmon byproducts (Salmo salar) generated by the food chain represent a source of long-chain polyunsaturated fatty acids (eicosapentaenoic acid (EPA): 20:5n-3; docosahexaenoic acid (DHA): 22:6n-3) and peptides that can be used as supplements in food for nutraceutical or health applications, such as in the prevention of certain pathologies (e.g., Alzheimer’s and cardiovascular diseases). The extraction of polar lipids naturally rich in PUFAs by enzymatic processes without organic solvent (controlled by pH-Stat method), coupled with the production of 1 kDa salmon peptides by membrane filtration, allowed the formulation of nanocarriers. The physicochemical properties of the nanoliposomes (size ranging from 120 to 140 nm, PDI of 0.27, zeta potential between −32 and −46 mV and encapsulation efficiency) were measured, and the bioactivity of salmon hydrolysate peptides was assessed (antioxidant and antiradical activity: ABTS, ORAC, DPPH; iron metal chelation). Salmon peptides exhibited good angiotensin-conversion-enzyme (ACE) inhibition activity, with an IC50 value of 413.43 ± 13.12 µg/mL. Cytotoxicity, metabolic activity and proliferation experiments demonstrated the harmlessness of the nanostructures in these experimental conditions.
Fichier principal
Vignette du fichier
marinedrugs-20-00249-v3 (1).pdf (1.4 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-03881122 , version 1 (01-12-2022)

Identifiants

Citer

Amine Hanachi, Arnaud Bianchi, Cyril J F Kahn, Emilie Velot, Elmira Arab-Tehrany, et al.. Encapsulation of salmon peptides in marine liposomes: physico-chemical properties, antiradical activities and biocompatibility assays. Marine drugs, 2022, 20 (4), pp.249. ⟨10.3390/md20040249⟩. ⟨hal-03881122⟩
68 Consultations
32 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More