An expedient and short synthesis of chiral α-hydrazinoesters: synthesis and conformational analysis of 1:1 [α/α-Nα-hydrazino]mers - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue Tetrahedron Année : 2012

An expedient and short synthesis of chiral α-hydrazinoesters: synthesis and conformational analysis of 1:1 [α/α-Nα-hydrazino]mers

Résumé

Different alpha-hydrazinoesters with high optical purity have been obtained in large scale via a SN2 protocol. A coupling reaction with a natural aminoacid leads to the corresponding dimers which have been oligomerized in order to obtain the 1:1 [alpha/alpha-Nalpha-hydrazino]mer series.. Conformational studies show that these mixed oligomers are self-organized in solution via a succession of gamma-turn and hydrazinoturn whatever the absolute configuration of the chiral carbons.
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hal-03973827 , version 1 (04-02-2023)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Ralph-Olivier Moussodia, Samir Acherar, Andrea Bordessa, Régis Vanderesse, Brigitte Jamart-Grégoire. An expedient and short synthesis of chiral α-hydrazinoesters: synthesis and conformational analysis of 1:1 [α/α-Nα-hydrazino]mers. Tetrahedron, 2012, 68 (24), pp.4682-4692. ⟨10.1016/j.tet.2012.04.018⟩. ⟨hal-03973827⟩
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