Fluorescent and magnetic Mn-Gd or Fe-doped Ag-In-Zn-S QDs : Aqueous synthesis and characterization - Université de Lorraine Access content directly
Conference Papers Year : 2023

Fluorescent and magnetic Mn-Gd or Fe-doped Ag-In-Zn-S QDs : Aqueous synthesis and characterization

Abstract

Ternary quantum dots (QDs) such as AgInS2 (AIS) have been demonstrated to be very attractive for biomedical applications due to their small size, composition tunable optical and electrical properties and low toxicity. To improve their photoluminescence properties, shelling with ZnS is well developed, which led to quaternary Ag-In-Zn-S (AIZS) QDs. The synthesis of AIZS QDs in aqueous media is developing because the obtained nanocrystals do not require a post-preparative step for their water dispersion. Furthermore, aqueous synthesis is of low-cost, environmental-friendly and mild synthesis conditions allow large-scale synthesis. The synthesis of highly fluorescent AIZS and Mn2+, Gd3+ or Fe3+-doped AIZS QDs was carried out in aqueous media using reduced L-glutathione (GSH) as a capping ligand. Folic acid (FA) was used as the surface targeting ligand to adapt AIZS QDs for biomedical applications. For this purpose, PEI-FA conjugate was first prepared, then, the positively charged PEI-FA conjugate was associated to negatively charged carboxylate groups of GSH-capped QDs. AIZS and Mn, Gd or Fe-doped AIZS QDs exhibit a cubic ZnS blende structure and average diameters are in the range of 2.2 to 2.5 nm. The doped QDs show superparamagnetic and paramagnetic properties. MTT assay results indicate that synthesized QDs showed no toxicity towards KB cells when incubated for one day at a concentration of 1 mg/mL. Moreover, GSH-PEI-FA-capped QDs were used for in vitro bioimaging tests. The efficient labeling of cells using these QDs indicates that the FA-conjugation has been successful and facilitates specific intracellular uptake, which occurs mainly through receptor-mediated endocytosis.
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Dates and versions

hal-04144102 , version 1 (28-06-2023)

Identifiers

  • HAL Id : hal-04144102 , version 1

Cite

Perizat Galiyeva, Henri-Pierre Lasalle, Bolat Uralbekov, Raphaël Schneider. Fluorescent and magnetic Mn-Gd or Fe-doped Ag-In-Zn-S QDs : Aqueous synthesis and characterization. 9th Nanotech & Nanomaterials Research Conference, Nano Rome 2023, Jun 2023, Rome, Italy. ⟨hal-04144102⟩
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