This work deals with the potential of the Al/AlN/Sapphire surface acoustic wave (SAW) structure as wireless sensor operating in the 2.45 GHz ISM band for high-temperature applications up to 500 °C. A first design was used to make SAW resonators by e-beam lithography and characterize them between room temperature and 500 °C in a wired configuration. Frequency variation with temperature showed good stability, repeatability, linearity, and sensitivity with a measured temperature coefficient of frequency (TCF) of -47 ppm/°C. The figure of merit, defined by the product of the electromechanical coupling coefficient and the quality factor, value varies between 0.8 and 2 throughout the whole temperature range, proving the potential of the structure for wireless interrogation at high temperature. Consequently, the SAW resonator was successfully wirelessly interrogated up to 500 °C at a distance of 1 m. Moreover, wireless interrogation of the sensor was possible up to 3 m at room temperature, with additional path losses of 19 dB, which could prove troublesome for operating temperatures above 400 °C. An optimization of the SAW resonator design was then subsequently carried out by simulation means in order to improve the figure of merit and allow wireless interrogation at higher temperatures and greater distances.