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Les glutarédoxines : de la réduction des peroxyrédocines de type II aux systèmes d'assemblage des centres fer-souffre

Abstract : Environment variations can modify plant metabolism in particular by production of reactive oxygen species (ROS) which are harmfull at high level. Enzymatic systems are to degrade these ROS but also repair oxidized molecules. They are composed by peroxidases (thioredoxins-reduced glutathione peroxidases and thioredoxin or glutaredoxin-reduced peroxiredoxins) using dithiol exchange for their activity. These systems present a complexity according to their multigenic family origin. Recombinant Prx-Grx hybrids have been produced giving clue to interactions between Prx and Grx. Enzymatic studies showed Prx IIF and IIE can reduced a wide range of substrates other than hydrogen peroxide, with variable activity. Furthermore they are not found identically in plant tissue and react to oxidative stress in different ways. Besides reducing properties Grx could participate in cell signalling by glutathionylation, mechanism which protects cystein by fixating a molecule of GSH. A new role appeared recently, they help production of iron-sulfur cluster and play a role in iron-sulfur proteins maturation. Plastidials S14 and S16 Grxs can naturally bind an iron-sulfur cluster and complement Grx5 (CGFS Grx known entering in iron-sulfur proteins maturation) deficient mutants yeast. Finally GrxS14 is able to transfer efficiently his cluster to accepting molecule. These results allow us understanding better these multigenic families regulating several physiological processes, some still unknown, in oxidative stress
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Submitted on : Thursday, March 29, 2018 - 10:32:58 AM
Last modification on : Wednesday, September 8, 2021 - 4:02:07 PM
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  • HAL Id : tel-01746381, version 1



Filipe Gama. Les glutarédoxines : de la réduction des peroxyrédocines de type II aux systèmes d'assemblage des centres fer-souffre. Sylviculture, foresterie. Université Henri Poincaré - Nancy 1, 2010. Français. ⟨NNT : 2010NAN10116⟩. ⟨tel-01746381⟩



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