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Modification chimique d'antioxydants pour les rendre lipophiles : application aux tannins

Abstract : In the order to use natural antioxidants in lipidic substances, we wanted to make lipophilic of tannins by grafting on them carbonaceous chains through mild and simple chemical modifications. First, we used model substrates of tannins (phenol, catechol, gallic acid and mostly catechin) in experiments of alkylation, acylation, esterification by a fatty acid or a fatty alcohol, or, with regard to catechin, grafting of a carbonaceous chain variable length by a coupling reaction of the oxa-Pictet-Spengler type between the cycles C and B. Then, an application of the same synthesis to tannins of chestnut (Castanea sativa), oak (Quercus pedunculata), quebracho (Schinopsis balansae) and grape seed (Vitis vinifera) was a success, especially for the coupling oxa-Pictet-Spengler. All derivatives of model molecules or rough tannins acquired a lipophilic character as proven by the measurement of the coefficient of partition between water and the octanol. The antioxidant properties of model molecules, rough and modified tannins were measured by two methods: inhibition of the induced oxidation of the methyl linoleate and reactivity with the free radical 2,2-diphenyl-picrylhydrazyle (DPPH). The antioxidant properties are well preserved after modification.
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  • HAL Id : tel-01748348, version 1

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Bouddah Poaty-Poaty. Modification chimique d'antioxydants pour les rendre lipophiles : application aux tannins. Autre. Université Henri Poincaré - Nancy 1, 2009. Français. ⟨NNT : 2009NAN10033⟩. ⟨tel-01748348⟩

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