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Extrapolation du procédé de granulation humide en mélangeur haute vitesse

Abstract : Controlling wet granulation process scale-up is still today a challenge due to the lack of tools which could describe quite accurately the mechanisms of granule growth in high shear mixers. The well-known approach consisting in characterizing a mixing process of liquid phases with non-dimensional numbers has therefore been applied to the granular medium in the high shear mixer to establish a correlation between MiPro Pro-C-epT mixers of 3 different scales. In that frame, a method to measure the consistency of the powder has been developed.In addition, the influence of key operating variables on the granule size distributions has been studied by using a D-optimal experimental plan. The results obtained allowed to conclude that phase transitions during granulation appear at constant liquid/powder ratio whatever the scale of the mixer. Finally, the granule growth kinetic has been determined in the small scale mixer and this allowed to characterize the granule growth mechanism in small scale mixer as being mainly driven by a fragmentation-layering process
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Anne-Laure Bouillon Bouillon-Camara. Extrapolation du procédé de granulation humide en mélangeur haute vitesse. Autre. Institut National Polytechnique de Lorraine, 2005. Français. ⟨NNT : 2005INPL060N⟩. ⟨tel-01748884⟩



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