Contribution de l'environnement résidentiel à l'exposition au plomb des enfants de 6 mois à 6 ans en France, 2008-2009

Abstract : Exposure to lead decreased drastically in last decades. However, it remains a public health concern, due to the accumulation of evidence on the adverse health effects at low doses. Primary prevention is considered crucial for these blood lead levels below the action level of 100 µg/L. To date in France, environmental determinants of moderate blood lead levels and their impacts are not documented. The objective of this thesis is to estimate the contribution of residential sources to lead exposure for children 6 months to 6 years in France. This work is based on the analysis of exposure data representative of children aged from 6 months to 6 years, both in children's blood (lead content) and their residential environment (lead in water, soil and dust). The analysis was based on 1) the comparison of isotopic signatures of lead to identify exposure sources 2) a regression model between blood and environmental lead concentrations. The analysis showed a multi-source residential exposure, with great impact of exposures to low environmental lead concentrations at a population-level, particularly in dust. This reinforces the need for general preventive measures to further reduce low exposures. For the highest exposures, the potential impact of hypothetical standard concentrations was evaluated
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Youssef Oulhote. Contribution de l'environnement résidentiel à l'exposition au plomb des enfants de 6 mois à 6 ans en France, 2008-2009. Médecine humaine et pathologie. Université de Lorraine, 2012. Français. ⟨NNT : 2012LORR0007⟩. ⟨tel-01749156⟩

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