Caractérisation de tissus cutanés superficiels hypertrophiques par spectroscopie multimodalité in vivo : instrumentation, extraction et classification de données multidimensionnelle

Abstract : This research activity aims at developing and validating a multimodal system combining diffuse reflectance spectroscopy and autofluorescence spectroscopy in characterizing hypertrophic scar tissues in vivo. The work relies on three axes. The first part concerns the development of an automatic system which is suitable for multimodal spectroscopic measurement. A series of calibration procedures are carried out for ensuring the reliability of the measurement result. The second part presents a preclinical study on an animal model (rabbit ear). An experimental protocol was implemented in order to create hypertrophic scars on which we can collect spectra to analyze. The third part deals with the classification problem on the spectra obtained. It provides a series of algorithmic methods for denoising and correcting the measured spectra, for automatically extracting some interpretable spectral features and for selecting an optimal subset for classification. The classification results arched using respectively 3 different classifiers (knn, LDA and ANN) show the ability of bimodal spectroscopy in characterization of the topic skin lesion. Furthermore, the features selected my selection method indicate that the hypertrophic scarring may involve a change in tissue structure and in the concentration of porphyrins embedded in the epidermis
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Honghui Liu. Caractérisation de tissus cutanés superficiels hypertrophiques par spectroscopie multimodalité in vivo : instrumentation, extraction et classification de données multidimensionnelle. Autre. Université de Lorraine, 2012. Français. ⟨NNT : 2012LORR0032⟩. ⟨tel-01749199⟩

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