Développement de biomatériaux nanostructurés pour la régénération osseuse et ostéo-articulaire

Abstract : During the last ten years, tissue engineering has merged with regenerative nanomedecine by combination, not only of stem cell technology but also of growth factors. The goal of this thesis was to use bone and cartilage engineering as a model, in order to improve and to develop active and living nanostructured implants. During this PhD studies, we were interested in the development of biomaterials (natural or synthetic), tridimentionnal (3D), transplantable for bone and cartilage diseases treatments, that are able to induce more cellular differentiation and improved tissue regeneration. In this thesis, we have developed 3 types of nanostructured implants, (i) titanium implants coated with hydroxyapatite and carbone nanotubes; (ii) active capsules functionalized by growth factors and stems cells for bone induction (in vitro/in vivo); (iii) electrospun nanofibrous membranes functionalized by growth factors and (Osteoblasts/Chondrocytes) for bone and cartilage regeneration, in vitro and in vivo
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Sybille Facca. Développement de biomatériaux nanostructurés pour la régénération osseuse et ostéo-articulaire. Médecine humaine et pathologie. Université de Lorraine, 2012. Français. ⟨NNT : 2012LORR0234⟩. ⟨tel-01749626⟩

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