Mesure de bioimpédance électrique par capteurs interdigités

Abstract : The characterization by impedance spectroscopy of biological micro samples is one of the objectives of this thesis. The well known polarization phenomena at low frequency is a constraint that increases the measurement error. The main objective of this thesis is to optimize the geometric structure of an interdigitated electrode sensor in order to obtain confident experimental results in an extended useful frequency band without a significant influence of the polarization effect. The first chapter synthesizes fundamental data on the electrical behavior of biological tissues and their electrical properties. A state of the art techniques of the fundamental impedance measurement based on micrometric electrodes is also presented. The second chapter developps a theoretical approach for optimization of the biosensor. This optimization is used to expand the usable measurement. Indeed, it leads to determine the optimum distance between electrodes versus electrode width. A 3D modeling of the electrode system loaded by a biological medium was simulated using ConventorWare and the results are discussed. In the third chapter, the devices developed in this work are described. Design and manufacture of the biosensor components are described. In the last chapter, measurements on microvolumes of fluids (standard solutions, human blood) using five micros sensors with interdigitated electrodes are presented and discussed. Finally we compare these results to published values in the literature and the optimization theory is experimentally validated
Complete list of metadatas

Cited literature [95 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/tel-01749652
Contributor : Thèses Ul <>
Submitted on : Thursday, March 29, 2018 - 12:22:22 PM
Last modification on : Tuesday, March 12, 2019 - 3:52:07 PM
Long-term archiving on: Monday, September 17, 2018 - 12:36:53 PM

File

DDOC_T_2012_0307_IBRAHIM.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : tel-01749652, version 1

Collections

Citation

Mouhamad Ibrahim. Mesure de bioimpédance électrique par capteurs interdigités. Médecine humaine et pathologie. Université de Lorraine, 2012. Français. ⟨NNT : 2012LORR0307⟩. ⟨tel-01749652⟩

Share

Metrics

Record views

58

Files downloads

217