Synthèse contrôlée et auto-organisation de glycopolymères amphiphiles à greffons polymères mésogènes, destinés à la vectorisation de principes actifs

Abstract : New graft glycopolymers with well-defined parameters [dextran-g-poly(diethylene glycol cholesteryl ether acrylate) (Dex-g-PADEGChol)] have been prepared in four steps using the "grafting from" strategy. Challenge of this work arises from the combination for the first time of a hydrophilic, biocompatible/biodegradable polysaccharide backbone with mesogen hydrophobic polymeric grafts. Controlled growth of the grafts (PADEGChol) was obtained using ATRP initiated in homogeneous medium from a dextran derivative (DexAcBr). In order to find the best polymerization conditions, homopolymerization of ADEGChol monomer was investigated using an initiator model and various catalytic systems CuIBr/(PMDETA or OPMI) in two solvents (Toluene and THF). The amphiphilic properties of such glycopolymers were evaluated and their mesomorphic properties have been studied by thermal polarizing optical microscopy, differential scanning calorimetry and X-ray scattering. Using transmission electron microscopy and dynamic light scattering, vesicular morphology called "polymersome" was observed in aqueous medium when DMSO was used as co-solvent. These polymersomes could be tested as new drug delivery systems
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Khalid Ferji. Synthèse contrôlée et auto-organisation de glycopolymères amphiphiles à greffons polymères mésogènes, destinés à la vectorisation de principes actifs. Autre. Université de Lorraine, 2013. Français. ⟨NNT : 2013LORR0118⟩. ⟨tel-01750371⟩

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