Diagnostic des pathologies plaquettaires : optimisation de l'exploration des granules denses plaquettaires

Abstract : Platelets play an essential role in the hemostasis. Abnormalities in platelet number or platelet function may result in excessive bleeding. Diagnosis of platelet disorders requires platelet count and platelet function testing. Our work is aimed to improve the diagnosis of platelet disorders, especially to develop new approaches for testing the function of platelet dense granules. Inherited platelet disorders are hardly recognized in China. Therefore we published an article in Chinese on the topic of hereditary thrombocytopenia in a Chinese clinical journal, within the framework of collaboration between Nancy and Wuhan. In addition, we evaluated the usefulness of flow cytometric mepacrine assay combined with CD63 expression in the diagnosis of dense granule disorder. Moreover, our work demonstrates that vitamin C deficiency might be associated with platelet dense granule disorder. Finally, we developed a method by flow cytometry and then by HPLC for detection of platelet serotonin
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Huili Cai. Diagnostic des pathologies plaquettaires : optimisation de l'exploration des granules denses plaquettaires. Médecine humaine et pathologie. Université de Lorraine, 2015. Français. ⟨NNT : 2015LORR0067⟩. ⟨tel-01751698⟩

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