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Etude du transfert diffusionnel de solutés macromoléculaires dans les hydrogels d'alginate de calcium :

Abstract : This study deals with diffusion of macromolecules (pullulans with a large range of molecular weights standing from 780 to 788 000 g.mol-1) into spherical particles of calcium alginate hydrogel. Thanks to variations of polymer volumic fraction in the hydrogel and of solute molecular weight, different experimental situations have been experimented. Measurements of diffusion kinetics have been performed with 3 independent methods which have demonstrated various adaptability to this situation: uptake experiments using or not an analysis loop and column experiments. This assays showed that uptake experiments with an analysis loop is more convenient. Effect of the analytic loop on the results has been studied and lead to the definition of experimental recommendations. Moreover, a parameters sensibility analysis enables the determination of an optimum of sensibility for diffusion coefficient determination. Applying these recommendations, diffusion and partition coefficients have been estimated. Characterisation of the system alginate/pullulan and transfert data were used to modelling relationships between structural and diffusional properties. Both results obtained in diffusion and partition showed that a hydrodynamic approach postulating a porous model for the gel gave the best adequation between models and experiments.
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Delphine Mazens. Etude du transfert diffusionnel de solutés macromoléculaires dans les hydrogels d'alginate de calcium :. Autre. Institut National Polytechnique de Lorraine, 2005. Français. ⟨NNT : 2005INPL118N⟩. ⟨tel-01752497⟩



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