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Etude de nouveaux photosensibilisants pour des applications en Thérapie Photodynamique

Abstract : Derived of porphyrins are tetrapyrrolic macrocycles involved in several redox processes. These compounds are used for different biological applications, like photodynamic therapy (PDT). Many teams in the world seek to synthesize compounds able to directly recognize specifically and (by targeting) or indirectly (by vectorization) cancer cells. These compounds are known as of 3rd generation. We are involved in the synthesis and the biological evaluation of tetrapyrrolic compounds associated to recognition and/or transport agents such as sugars or RGD-like peptide sequences. These moieties allow a specific recognition of the cancerous cells, via the lectins for the sugar moieties and the integrins for the RGD type moieties, respectively. Within the framework of an European Cost-Chemistry program entitled "New mo/ecu/ar systems with therapeutic applications in photodynamic therapy of cancer and microbia/ infections", we also studied the photophysical properties of photosensitizers synthesized by a Rumanian team
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Benoît Di Stasio. Etude de nouveaux photosensibilisants pour des applications en Thérapie Photodynamique. Biotechnologies. Institut National Polytechnique de Lorraine, 2006. Français. ⟨NNT : 2006INPL069N⟩. ⟨tel-01752766⟩



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