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Impact of the administration of α-casozepine, a benzodiazepine-like peptide from bovine αs1-casein, and of a proteolysis fragment on neural activity in mice

Abstract : Α-casozepine (α-CZP) is a decapeptide that mediates the anxiolytic-like properties of the tryptic hydrolysate of bovine αs1-casein. Different properties of α-CZP leads to consider this peptide close to the benzodiazepine family, the most commonly used anxiolytic molecules. In contrast, other results suggest a distinct mode of action between α-CZP and benzodiazepines, especially the fact that the peptide does not have side effects. Although a central action remains the main hypothesis of the mode of action of α-CZP, no regulation of the brain activity has been shown before. The work achieved in this thesis displayed the fact that the anxiolytic-like properties of α-CZP, after a single intraperitoneal injection of the peptide, are associated with a modulation of cerebral activity in several regions linked to anxiety regulation in mice brains, such as the amygdala, the hippocampal formation, the accumbens nucleus and some nuclei of the hypothalamus or raphe. Besides, these modulations of neural activity are not exactly the same as those obtained after an injection of diazepam, a reference benzodiazepine, or YLGYL, a derivative of α-CZP, even though observed behaviours are similar. Eventually, it has been demonstrated that an anxiety-inducing situation is needed to trigger the central effects of α-CZP. This work allowed a better understanding of the mode of action of a bioactive peptide from alimentary origin that has a positive action on its consumer’s mood and behaviour
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https://hal.univ-lorraine.fr/tel-01916531
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Simon Benoit. Impact of the administration of α-casozepine, a benzodiazepine-like peptide from bovine αs1-casein, and of a proteolysis fragment on neural activity in mice. Agronomy. Université de Lorraine, 2017. English. ⟨NNT : 2017LORR0345⟩. ⟨tel-01916531⟩

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