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Synthèse et caractérisation de nanoparticules magnétiques répondantes pour des applications en thérapie cancéreuse

Abstract : In the frame of this PhD project, smart superparamagnetic nanoparticles (SPIONs) have been developed for a further use as a drug platform for cancer therapy. These nanoparticles of core / shell type are obtained from the functionalization of a core based on Fe3-δO4 by a co- polymer obtained from the surface-initiated polymerization of a mixture xMEO2MA and yOEGMA (x + y = 1). Once their structures and their colloidal behavior in water and in-vitro perfectly characterized as well as the demonstration of their thermo-responsive properties, studies of encapsulation and release of an anti-cancer drug, the doxorubicin (DOX) at physiological temperatures were successfully obtained. In-vitro studies showed the non- cytotoxicity of the nanoparticles, but when the cancer cells were in contact the DOX-loaded NPs, the cytotoxicity was increased. To induce the targeting of ovarian cancer (SKOV3 cells) and the enhancement of the internalization of nanoparticles in cells, we have functionalized the previous nanoparticles with folic acid as these last cells over-express receptors that bind folate α (FR-α ). The combination of different macroscopic and nanometric scale characterization techniques allowed us to conclude that our systems are capable of encapsulating DOX, releasing it in a specific manner and at a controlled rate and that they exhibit hyperthermia properties. We have then contributed to successfully develop new third generation vectors for cancer therapy.
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Submitted on : Monday, June 22, 2020 - 2:07:31 PM
Last modification on : Tuesday, January 4, 2022 - 6:30:46 AM


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Zied Ferjaoui. Synthèse et caractérisation de nanoparticules magnétiques répondantes pour des applications en thérapie cancéreuse. Science des matériaux [cond-mat.mtrl-sci]. Université de Lorraine, 2020. Français. ⟨NNT : 2020LORR0013⟩. ⟨tel-02877472⟩



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