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Evaluation of innate lymphoid cells, mucosal-associated invariant T cells and helper T cells in human autoimmune uveitis

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Abstract

Up to 50 % of uveitis are classified as « idiopathics ». Uveitis association with Th1 and Th17-mediated systemic inflammatory disorders-such as IBD and spondylarthritis-and immunosuppressive agents efficacy suggest underlying autoimmune mechanisms. Specific T cell responses to retinal antigens (IRBP and S-arrestin) have been identified in patients with idiopathic uveitis. A transgenic murine model of spontaneous autoimmune uveitis recently showed that specific retinal antigen T cells were initially activated in the intestine by microbiota extracts before they migrated and entered into the eye (1). Innate lymphoid cells (ILC) and mucosal-associated invariant T cells (MAIT) are innate immune cells recently discovered and particularly represented in mucosal tissues. These cells have never been evaluated in human uveitis. Objective : To study circulating ILC, MAIT and T lymphocytes in human autoimmune uveitis Elevation of Th17 cells in uveitis patients compared to controls at diagnosis patients controls.
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Dates and versions

hal-02986074 , version 1 (02-11-2020)

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Attribution - CC BY 4.0

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  • HAL Id : hal-02986074 , version 1

Cite

Paul Decker, Thomas Moulinet, Rolland Jaussaud, Maxime Cravat, Jérémy Corriger, et al.. Evaluation of innate lymphoid cells, mucosal-associated invariant T cells and helper T cells in human autoimmune uveitis. 52nd Annual Meeting of the French Society for Immunology, Nov 2019, Nantes, France. ⟨hal-02986074⟩
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