Skip to Main content Skip to Navigation
Poster communications

Evaluation of innate lymphoid cells, mucosal-associated invariant T cells and helper T cells in human autoimmune uveitis

Abstract : Up to 50 % of uveitis are classified as « idiopathics ». Uveitis association with Th1 and Th17-mediated systemic inflammatory disorders-such as IBD and spondylarthritis-and immunosuppressive agents efficacy suggest underlying autoimmune mechanisms. Specific T cell responses to retinal antigens (IRBP and S-arrestin) have been identified in patients with idiopathic uveitis. A transgenic murine model of spontaneous autoimmune uveitis recently showed that specific retinal antigen T cells were initially activated in the intestine by microbiota extracts before they migrated and entered into the eye (1). Innate lymphoid cells (ILC) and mucosal-associated invariant T cells (MAIT) are innate immune cells recently discovered and particularly represented in mucosal tissues. These cells have never been evaluated in human uveitis. Objective : To study circulating ILC, MAIT and T lymphocytes in human autoimmune uveitis Elevation of Th17 cells in uveitis patients compared to controls at diagnosis patients controls.
Document type :
Poster communications
Complete list of metadatas

https://hal.univ-lorraine.fr/hal-02986074
Contributor : Marcelo de Carvalho <>
Submitted on : Monday, November 2, 2020 - 4:27:51 PM
Last modification on : Wednesday, November 4, 2020 - 3:34:08 AM

File

Poster SFI2019 VF.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

  • HAL Id : hal-02986074, version 1

Collections

Citation

Paul Decker, Thomas Moulinet, Rolland Jaussaud, Maxime Cravat, Jérémy Corriger, et al.. Evaluation of innate lymphoid cells, mucosal-associated invariant T cells and helper T cells in human autoimmune uveitis. 52nd Annual Meeting of the French Society for Immunology, Nov 2019, Nantes, France. ⟨hal-02986074⟩

Share

Metrics

Record views

8

Files downloads

7