Evaluation of innate lymphoid cells, mucosal-associated invariant T cells and helper T cells in human autoimmune uveitis
Résumé
Up to 50 % of uveitis are classified as « idiopathics ». Uveitis association with Th1 and Th17-mediated systemic inflammatory disorders-such as IBD and spondylarthritis-and immunosuppressive agents efficacy suggest underlying autoimmune mechanisms. Specific T cell responses to retinal antigens (IRBP and S-arrestin) have been identified in patients with idiopathic uveitis. A transgenic murine model of spontaneous autoimmune uveitis recently showed that specific retinal antigen T cells were initially activated in the intestine by microbiota extracts before they migrated and entered into the eye (1). Innate lymphoid cells (ILC) and mucosal-associated invariant T cells (MAIT) are innate immune cells recently discovered and particularly represented in mucosal tissues. These cells have never been evaluated in human uveitis. Objective : To study circulating ILC, MAIT and T lymphocytes in human autoimmune uveitis Elevation of Th17 cells in uveitis patients compared to controls at diagnosis patients controls.
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