How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms? - Université de Lorraine
Article Dans Une Revue NPJ Microgravity Année : 2024

How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Trent Davis (1) , Kevin Tabury (2) , Shouan Zhu (1) , Debora Angeloni (3) , Sarah Baatout (2) , Alexandra Benchoua (4) , Juergen Bereiter-Hahn (5) , Daniele Bottai (6) , Judith-Irina Buchheim (7) , Marco Calvaruso (8) , Eugénie Carnero-Diaz (9) , Sara Castiglioni (6) , Duccio Cavalieri (10) , Gabriele Ceccarelli (11) , Alexander Choukér (7) , Francesca Cialdai (10) , Gianni Ciofani (12) , Giuseppe Coppola (13) , Gabriella Cusella (11) , Andrea Degl’innocenti (14) , Jean-Francois Desaphy (15) , Jean-Pol Frippiat (16) , Michael Gelinsky (17) , Giada Genchi (12) , Maria Grano (15) , Daniela Grimm (18) , Alain Guignandon (19) , Christiane Hahn (20) , Jason Hatton (20) , Raúl Herranz (21) , Christine Hellweg (22) , Carlo Saverio Iorio (23) , Thodoris Karapantsios (24) , Jack J.W.A. van Loon (25) , Matteo Lulli (10) , Jeanette Maier (6) , Jos Malda (26, 27) , Emina Mamaca (28) , Lucia Morbidelli (14) , Angelique van Ombergen (20) , Andreas Osterman (29) , Aleksandr Ovsianikov (30) , Francesco Pampaloni (31) , Elizabeth Pavezlorie (32) , Veronica Pereda-Campos (33, 34) , Cyrille Przybyla (35) , Christopher Puhl (20) , Petra Rettberg (36) , Angela Maria Rizzo (6) , Kate Robson-Brown (37) , Leonardo Rossi (38) , Giorgio Russo (8) , Alessandra Salvetti (38) , Daniela Santucci (39) , Matthias Sperl (36) , Sara Tavella (40) , Christiane Thielemann (41) , Ronnie Willaert (42) , Nathaniel Szewczyk (1) , Monica Monici (10)
1 Ohio University
2 SCK-CEN - Centre d'Etude de l'Energie Nucléaire
3 SSSUP - Scuola Universitaria Superiore Sant'Anna = Sant'Anna School of Advanced Studies [Pisa]
4 I-STEM - Institut des cellules souches pour le traitement et l'étude des maladies monogéniques
5 Goethe University Frankfurt
6 UNIMI - Università degli Studi di Milano = University of Milan
7 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
8 CNR - Consiglio Nazionale delle Ricerche [Messina]
9 ISYEB - Institut de Systématique, Evolution, Biodiversité
10 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
11 UNIPV - Università degli Studi di Pavia = University of Pavia
12 IIT - Italian Institute of Technology = Istituto Italiano di Tecnologia
13 ISASI - Istituto di Scienze Applicate e Sistemi Intelligenti “Eduardo Caianiello”
14 UNISI - Università degli Studi di Siena = University of Siena
15 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
16 SIMPA - Stress, Immunité, Pathogènes
17 TU Dresden - Technische Universität Dresden = Dresden University of Technology
18 OVGU - Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg]
19 LBTO - Biologie Intégrative du Tissu Osseux
20 ESA - ESTEC (Netherlands)
21 CSIC - Consejo Superior de Investigaciones Científicas [Spain]
22 DLR Institute of Aerospace Medicine
23 ULB - Université libre de Bruxelles
24 Aristotle University of Thessaloniki
25 Amsterdam UMC - Amsterdam University Medical Centers
26 UMCU - University Medical Center [Utrecht]
27 Universiteit Utrecht / Utrecht University [Utrecht]
28 IFREMER - Institut Français de Recherche pour l'Exploitation de la Mer
29 MVP - Max Von Pettenkofer Institute
30 TU Wien - Vienna University of Technology = Technische Universität Wien
31 BMLS - Buchmann Institute for Molecular Life Sciences [Frankfurt am Main]
32 Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Research Center of AUVA
33 GSBMS - Groupement scientifique de Biologie et de Medecine Spatiale
34 EVOLSAN - Évolution et Santé Orale
35 UMR MARBEC - MARine Biodiversity Exploitation and Conservation - MARBEC
36 DLR - Deutsches Zentrum für Luft- und Raumfahrt [Köln]
37 University of Bristol [Bristol]
38 UniPi - University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie]
39 ISS - Istituto Superiore di Sanità = National Institute of Health
40 UniGe - Università degli studi di Genova = University of Genoa
41 Biomems lab
42 VUB - Vrije Universiteit Brussel [Bruxelles]
Trent Davis
Ohio University
Kevin Tabury
Centre d'Etude de l'Energie Nucléaire
Shouan Zhu
  • Fonction : Auteur
Ohio University
Debora Angeloni
  • Fonction : Auteur
Scuola Universitaria Superiore Sant'Anna = Sant'Anna School of Advanced Studies [Pisa]
Sarah Baatout
Centre d'Etude de l'Energie Nucléaire
Alexandra Benchoua
Institut des cellules souches pour le traitement et l'étude des maladies monogéniques
Juergen Bereiter-Hahn
  • Fonction : Auteur
Goethe University Frankfurt
Daniele Bottai
Università degli Studi di Milano = University of Milan
Judith-Irina Buchheim
  • Fonction : Auteur
Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
Marco Calvaruso
  • Fonction : Auteur
Consiglio Nazionale delle Ricerche [Messina]
Eugénie Carnero-Diaz
  • Fonction : Auteur
Institut de Systématique, Evolution, Biodiversité
Sara Castiglioni
  • Fonction : Auteur
Università degli Studi di Milano = University of Milan
Duccio Cavalieri
Università degli Studi di Firenze = University of Florence = Université de Florence
Gabriele Ceccarelli
  • Fonction : Auteur
Università degli Studi di Pavia = University of Pavia
Alexander Choukér
Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
Francesca Cialdai
  • Fonction : Auteur
Università degli Studi di Firenze = University of Florence = Université de Florence
Gianni Ciofani
Italian Institute of Technology = Istituto Italiano di Tecnologia
Giuseppe Coppola
  • Fonction : Auteur
Istituto di Scienze Applicate e Sistemi Intelligenti “Eduardo Caianiello”
Gabriella Cusella
  • Fonction : Auteur
Università degli Studi di Pavia = University of Pavia
Andrea Degl’innocenti
  • Fonction : Auteur
Università degli Studi di Siena = University of Siena
Jean-Francois Desaphy
Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
Jean-Pol Frippiat
Stress, Immunité, Pathogènes
Michael Gelinsky
Technische Universität Dresden = Dresden University of Technology
Giada Genchi
  • Fonction : Auteur
Italian Institute of Technology = Istituto Italiano di Tecnologia
Maria Grano
  • Fonction : Auteur
Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
Daniela Grimm
Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg]
Alain Guignandon
Biologie Intégrative du Tissu Osseux
CV
Christiane Hahn
  • Fonction : Auteur
ESA - ESTEC (Netherlands)
Jason Hatton
  • Fonction : Auteur
ESA - ESTEC (Netherlands)
Raúl Herranz
Consejo Superior de Investigaciones Científicas [Spain]
Christine Hellweg
DLR Institute of Aerospace Medicine
Carlo Saverio Iorio
  • Fonction : Auteur
Université libre de Bruxelles
Thodoris Karapantsios
Aristotle University of Thessaloniki
Jack J.W.A. van Loon
Amsterdam University Medical Centers
Matteo Lulli
Università degli Studi di Firenze = University of Florence = Université de Florence
Jeanette Maier
  • Fonction : Auteur
Università degli Studi di Milano = University of Milan
Jos Malda
  • Fonction : Auteur
University Medical Center [Utrecht]
Universiteit Utrecht / Utrecht University [Utrecht]
Emina Mamaca
  • Fonction : Auteur
Institut Français de Recherche pour l'Exploitation de la Mer
Lucia Morbidelli
  • Fonction : Auteur
Università degli Studi di Siena = University of Siena
Angelique van Ombergen
  • Fonction : Auteur
ESA - ESTEC (Netherlands)
Andreas Osterman
  • Fonction : Auteur
Max Von Pettenkofer Institute
Aleksandr Ovsianikov
Vienna University of Technology = Technische Universität Wien
Francesco Pampaloni
Buchmann Institute for Molecular Life Sciences [Frankfurt am Main]
Elizabeth Pavezlorie
  • Fonction : Auteur
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Research Center of AUVA
Veronica Pereda-Campos
Groupement scientifique de Biologie et de Medecine Spatiale
Évolution et Santé Orale
Cyrille Przybyla
  • Fonction : Auteur
MARine Biodiversity Exploitation and Conservation - MARBEC
Christopher Puhl
  • Fonction : Auteur
ESA - ESTEC (Netherlands)
Petra Rettberg
Deutsches Zentrum für Luft- und Raumfahrt [Köln]
Angela Maria Rizzo
Università degli Studi di Milano = University of Milan
Kate Robson-Brown
  • Fonction : Auteur
University of Bristol [Bristol]
Leonardo Rossi
  • Fonction : Auteur
University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie]
Giorgio Russo
  • Fonction : Auteur
Consiglio Nazionale delle Ricerche [Messina]
Alessandra Salvetti
  • Fonction : Auteur
University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie]
Daniela Santucci
Istituto Superiore di Sanità = National Institute of Health
Matthias Sperl
Deutsches Zentrum für Luft- und Raumfahrt [Köln]
Sara Tavella
Università degli studi di Genova = University of Genoa
Christiane Thielemann
Biomems lab
Ronnie Willaert
Vrije Universiteit Brussel [Bruxelles]
Nathaniel Szewczyk
Ohio University
Monica Monici
Università degli Studi di Firenze = University of Florence = Université de Florence

Résumé

Abstract Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.

Domaines

Sciences du Vivant [q-bio]

Jean-Pol Frippiat  : Connectez-vous pour contacter le contributeur

https://hal.univ-lorraine.fr/hal-04450577

Soumis le : samedi 10 février 2024-14:58:59

Dernière modification le : dimanche 17 novembre 2024-14:42:04

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Dates et versions

hal-04450577 , version 1 (10-02-2024)

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Citer

Trent Davis, Kevin Tabury, Shouan Zhu, Debora Angeloni, Sarah Baatout, et al.. How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?. NPJ Microgravity, 2024, 10 (1), pp.16. ⟨10.1038/s41526-024-00357-9⟩. ⟨hal-04450577⟩

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