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Vers un nouveau biosubstitut pour l'ingénierie tissulaire du Ligament Croisé Antérieur : Approche biomécanique

Abstract : Tissue engineering, which consists in replacing an injured tissue with a biodegradable scaffold seeded with cells, has the potential to overcome the limitations associated with current reconstructions strategies of the Anterior Cruciate Ligament (ACL). However, no relevant solution has been proposed yet, especially due to the variety of scientific fields involved in this approach. In the current study, the key requirements for the design of a new scaffold have been listed from the current state of art. A scaffold based on P(LL85/CL15) fibers arranged into a multilayer braided structure has been proposed, and the tools needed to process this scaffold have been developed. Dedicated numerical tools have been proposed in order to predict the morphological and multiscale biomechanical behavior of the scaffold. These simulation tools have enabled to optimize the scaffold geometry in order to match the selected key requirements for ACL tissue engineering. Moreover, preliminary biological assessments have shown that the scaffold was suited for the culture of stem cells and for tissue formation. In addition, a dedicated bioreactor has been developed in order to prescribe tension-torsion cycles within a controlled environment. The use of local information issued from the biomechanical simulations open large perspectives as far as the optimization of culture conditions and the understanding of mechanisms that govern the formation of a ligamentous tissue are concerned. As a conclusion, the present study is likely to enable a new solution for ACL tissue engineering to emerge in the next years.
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https://hal.univ-lorraine.fr/tel-01749742
Contributor : Cédric Laurent <>
Submitted on : Wednesday, March 15, 2017 - 9:08:28 AM
Last modification on : Monday, March 29, 2021 - 4:02:40 PM
Long-term archiving on: : Friday, June 16, 2017 - 12:42:44 PM

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  • HAL Id : tel-01749742, version 2

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Cédric Laurent. Vers un nouveau biosubstitut pour l'ingénierie tissulaire du Ligament Croisé Antérieur : Approche biomécanique . Biomécanique [physics.med-ph]. Université de Lorraine, 2012. Français. ⟨NNT : 2012LORR0073⟩. ⟨tel-01749742v2⟩

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